Multicompartmental Mathematical Model of SARS-CoV-2 Distribution in Human Organs and Their Treatment

Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety forms this disease requires further research on pathogenesis disease. Based analysis published data original experiments concentrations SARS-CoV-2 in biological fluids nasopharynx, lungs, intestines using a developed modular model virus distribution human tissue organs, an assessment reproduction various compartments body is presented. Most viral particles transport to esophagus from nasopharynx. The entering gastrointestinal tract will obviously be accompanied by infection intestinal epithelium accumulation lumen amount proportional their secretory protein-synthetic activities. relatively low concentration tissues implies essential role processes redistribution nasopharynx lungs. simulations also suppose that sanitation mucosa at initial stage infectious process has prospects for use medical practice.